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Synthesis and biological evaluation of 6H-1-benzopyrano[4,3-b]quinolin-6-one derivatives as inhibitors of colon cancer cell growth

机译：6H-1-苯并吡喃并[4,3-b]喹啉-6-酮衍生物的合成和生物学评价作为结肠癌细胞生长的抑制剂

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Tie-Ling Li; Hai-Feng Guo; Fu-Juan Li; Zhi-Guo Sun; Heng-Chun Zhang;
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年度 2015
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1. Ultrasound mediated catalyst free synthesis of 6H-1-benzopyrano[4,3-b] quinolin-6-ones leading to novel quinoline derivatives: Their evaluation as potential anti-cancer agents [J] . MulakayalaN., RambabuD., RajaM.R., Bioorganic and medicinal chemistry . 2012,第2期

机译：超声介导的无催化剂合成6H-1-苯并吡喃并[4,3-b]喹啉-6-酮类化合物，从而产生新型喹啉衍生物：作为潜在抗癌药的评估
2. Synthesis, characterization and biological evaluation of formononetin derivatives as novel EGFR inhibitors via inhibiting growth, migration and inducing apoptosis in breast cancer cell line [J] . Lin Hong-Yan, Sun Wen-Xue, Zheng Chao-Sai, RSC Advances . 2017,第76期

机译：通过抑制生长，迁移和乳腺癌细胞凋亡，乳腺癌蛋白衍生物作为新EGFR抑制剂的合成，表征和生物学评价
3. Synthesis, characterization and biological evaluation of formononetin derivatives as novel EGFR inhibitors via inhibiting growth, migration and inducing apoptosis in breast cancer cell line [J] . Hong-Yan Lin, Wen-Xue Sun, Chao-Sai Zheng, RSC Advances . 2017,第76期

机译：通过抑制乳腺癌细胞系生长，迁移和诱导细胞凋亡的formonnetin衍生物作为新型EGFR抑制剂 的合成，表征和生物学评价

4. Ability of Dibutyltin Polyamine Derivatives of Diaminopyrimidines to Inhibit Ovarian, Bone, Colon, Lung, and Breast Cancer Cells [C] . Kimberly Shahi, Michael R. Roner, Amitabh Battin PMSE Symposia . 2007

机译：二硫脲二聚胺衍生物的能力抑制卵巢，骨，结肠，肺和乳腺癌细胞的能力

5. Design and synthesis of molecular probes to modulate cell membrane permeation: I. Design, synthesis, and biological evaluation of novel chicoric acid analogues as inhibitors of HIV-1 integrase. II. Design, synthesis, and biological evaluation of novel estradiol analogues targeting the membrane estrogen receptor. [D] . Charvat, Trevor Thomas. 2004

机译：设计和合成的分子探针，可调节细胞膜的渗透性：I.设计，合成和生物评价作为抗HIV-1整合酶抑制剂的新型菊苣酸类似物。二。针对膜雌激素受体的新型雌二醇类似物的设计，合成和生物学评估。

6. Synthesis and biological evaluation of retinoid-chalcones as inhibitors of colon cancer cell growth [O] . Cassia S. Mizuno, Shiby Paul, Nanjoo Suh, -1

机译：类视黄芩酮的合成与生物学评价作为结肠癌细胞生长的抑制剂

7. Synthesis and biological evaluation of retinoid-chalcones as inhibitors of colon cancer cell growth [O] . Cassia S. Mizuno, Shiby Paul, Nanjoo Suh, 2010

机译：类视黄芩酮的合成与生物学评价作为结肠癌细胞生长的抑制剂

1. 微波促进的非催化合成香豆素并4,3-b 喹啉-6-酮衍生物 [J] . 曾竟 ,刘瑞姣 ,郭秀秀 . 化学研究与应用 . 2016,第006期

2. 2-氟-9,10-亚甲二氧基-6H-1苯并吡喃并4,3-b喹啉的合成与表征 [J] . 吴利欢 ,杨定乔 ,吕芬 . 化学试剂 . 2004,第2期

3. 1-羧甲基-3,3-二甲基-6-(对-甲基苯基)-1,2,3,4,5,6-六氢茚并2,3-b喹啉-5,11-二酮的微波合成和晶体结构 [J] . 陈艳 . 武汉大学学报：理学版 . 2007,第4期

4. 水介质中7-(4-溴苯基)-7,14-二氢化色烯并4,3-b苯并f喹啉-6-酮的合成及其晶体结构 [J] . 张梅梅 ,赵艳霞 ,魏志文 . 江苏师范大学学报（自然科学版） . 2009,第003期

5. 无溶剂条件下丙酸乙醇铵催化合成2-氨基-3-氰基-1，4，5，6-四氢吡喃并［3，2-c］喹啉-5-酮衍生物 [J] . 周忠强 ,余晓梦 . 中南民族大学学报（自然科学版） . 2015,第003期

6. 11-吗啉酰亚甲基-5,6-二氢-二苯并b,e氮杂(卓)-6-酮衍生物的合成及杀菌活性 [C] . LIANG Xiao-mei ,梁晓梅 ,Xiao Yan-shuang . 第十届全国新农药创制学术交流会 . 2013

7. (E)-2-芳烯基-3-氧代丁腈用于苯并硫氮杂卓及苯并吡喃[2,3-b]喹啉衍生物的合成 [A] . 赵立军 . 2013

1. 一种不对称催化合成四氢呋喃2,3-b苯并吡喃或四氢吡喃2,3-b苯并吡喃的方法 [P] . 中国专利： CN104945410A . 2015-09-30

2. 作为ALK抑制剂的5,6-二氢-11H-吲哚并2,3-B喹啉-11-酮化合物 [P] . 中国专利： CN110294750A . 2019-10-01

3. Polinucleotu00eddeo insulated tape of expression, host cell, isolated transgenic non-human animal polypeptide, which has been modified to express a polypeptide mutant with resistance to ALK, antibody that binds specifically to a polypeptide mutant with resistance to ALK, kit p For detection of a mutation with resistance to ALK inhibitor in a biological sample, and,Methods for evaluating a biological sample as a mutation with resistance to ALK inhibitor, for diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to evaluate a biological sample that Anto a mutation with resistance to ALK inhibitor.For diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to assess the biological sample as a mutation with resistance to ALK inhibitor, a cancer that is resistant to dianosticar Or is likely to develop resistance to PF - 02341066 in a pati [P] . 外国专利： BR112012026239A2 . 2016-11-29

机译：修饰的多聚核苷酸绝缘带，宿主细胞，分离的转基因非人类动物多肽，经过修饰以表达对ALK具有抗性的多肽突变体，与对ALK具有抗性的多肽突变体特异性结合的抗体，试剂盒p用于检测生物样品中对ALK抑制剂具有抗性的突变，以及用于评估生物样品为对ALK抑制剂具有抗性的突变的方法，用于诊断对至少一种对ALK抑制剂具有抗性或可能发展出抗性的癌症激酶小分子ALK，以评估Anto对ALK抑制剂具有抗性的突变的生物样品。用于诊断对至少一种激酶小分子ALK抑制剂具有抗药性或可能产生抗性的癌症，以评估该生物样品作为对ALK抑制剂有抗性的突变，即对狄诺司他抗性或可能对PF产生抗药性的癌症-02341066

4. isolated polynucleotide, expression cassette, host cell, isolated polypeptide, non-human transgenic animal that has been altered to express an alkali resistant mutant polypeptide, an antibody that specifically binds to an alkali resistant mutant polypeptide, a mutation detection kit alk inhibitor resistance in a biological sample, and methods for evaluating a biological sample for an alk inhibitor resistance mutation to diagnose cancer that is resistant to or likely to develop resistance to at least one alkaline inhibitor. small alk molecule kinase, to evaluate a biological sample for an alk inhibitor resistance mutation, to diagnose cancer that is resistant to or likely to develop resistance to pf-02341066 in a patient, to specifically reduce expression of an alk-resistant mutant to treat cancer associated with activating aberrant loop capacity that is resistant to at least one small molecule alk kinase inhibitor treating an aberrant cancer that is resistant to pf-02341066, identifyin [P] . 外国专利： BR112012026239A2 . 2018-06-26

机译：分离的多核苷酸，表达盒，宿主细胞，分离的多肽，已被改变以表达耐碱突变体多肽的非人类转基因动物，与耐碱突变体多肽特异性结合的抗体，突变检测试剂盒生物样品，以及用于评估生物样品中是否存在对烷基抑制剂的抗性突变以诊断对至少一种碱性抑制剂有抗药性或可能发展出抗药性的癌症的方法。小分子激酶，用于评估生物学样品中是否具有抑制碱性磷酸酶抑制剂的突变，以诊断对患者具有抗药性或可能对pf-02341066产生抗药性的癌症，从而特异性降低抗癌突变体的表达以治疗癌症与激活抗至少一种小分子烷基激酶抑制剂的异常环路能力有关，该抑制剂治疗对pf-02341066有抵抗力的异常癌症

5. EVALUATION METHOD OF COLON CANCER, COLON CANCER EVALUATION DEVICE, COLON CANCER EVALUATION METHOD, COLON CANCER EVALUATION SYSTEM, COLON CANCER EVALUATION PROGRAM AND RECORDING MEDIUM [P] . 外国专利： JP2013257350A . 2013-12-26

机译：结肠癌评估方法，结肠癌评估装置，结肠癌评估方法，结肠癌评估系统，结肠癌评估程序和记录介质

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Synthesis and biological evaluation of 6H-1-benzopyrano[4,3-b]quinolin-6-one derivatives as inhibitors of colon cancer cell growth

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